박용삼·양원용·고법민·양문호*
경희대학교
의과대학 성형외과학교실, 해부병리학교실*
A
Study on the Morphologic Change of the Tongue Muscle
in Down Syndrome Children.
Yong Sam Park, M.D.
Won Yong Yang, M.D., Bub Min Ko, M,D., Moon Ho Yang,
M.D.*
Department of Plastic and Reconstructive
Surgery, College of Medicine,
KyungHee University,
Department of AnatomicaI Pathology*
Anatomy
of oral cavity in Down syndrome is characterized
by hypotonic macroglossia, small oral cavity, narrow
palate with high-arch shape and hypertrophy of tonsil
and adenoid. Because of such a anatomic characteristics,
they show difficulty in respiration, mastication,
swallowing and articulation. So far we operated
on l35 children with Down syndrome for partial glossectomy
in average volume of 4.6cc. This study is histopathologic
finding of partially resected tongue in 4 cases,
analyzed by histochemical stain and electron microscopy.
The results of histochemicaI study showed predominant
of Type 2 myofiber and interstitial edema, fibrosis
and chronic nonspecific inflammation. In the study
of electron microscope, the size and number of mitochondria
were increased, but structural abnormality was not
showed .
Key
Words: Down syndrome, Tongue muscle biopsy |
