Retinoic acid modulates the level of nerve growth factor gene expression
and proliferation of cultured keratinocytes

ÀÌÁø¿ì, ÀÌ¿ë±Ç, Àüº¹È¯, À̹«Çü, ¹æ¿ø±â, Áø¿µ¿ì, Á¤³²Çö
Biotechnology letters 24 2002 2035-2040

Retinoic acid (RA) inhibited proliferation of cultured human keratinocytes. Southern blot analysis at 24h showed that RA inhibited nerve growth factor (NGF) mRNA synthesis in a dose-dependent manner. However, RA stimulated the production of NGF protein up to 187% of control after 96h and the treatment of cells with RA did not enhance apoptosis, either in the presence of low or high concentration of Ca2+, when compared to the control with DMSO.