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Sodium
sulfite is an antioxidant, a preservative and a
reducing agent, widely used in the foods, beverages,
drugs, cosmetics, and phrmaceutical industries.
Oral ingestion or inhalation of it in asthmatic
patients may prov oke asthmatic attack, urticaria,
angioedema, and anaphylaxis. A 28-year-old male
presented with well-demarcated erythematous scaly
patch with itching sensation on the left lower leg.
He had applied Nizoral cream on the erythematous
patch of the left lower leg for 7 days and the skin
lesion was aggravated. Patch tests with Nizoral
cream 'as is' showed positive reaction and
sodium sulfite, the ingredient of Nizoral cream,
revealed positive reaction. |