박지용
윤정빈 이무형 대피지 2000:38:5 600-606
Background
: Lichen striatus is an uncommon dermatoses that
generally affects children. The histopathology often
shows a polymorphic epidermal reaction process of
variable lichenoid and spongiotic changes having
no specific histpathological criteria. The pathologenesis
of lichen striatus is not well understood. A cell
mediated immunologic mechanism is suggested as primary
event in lichen striatus. Objective : The aim of
our study was to evaluate clinical, histopathological
and immunohistochemical findings that help to understand
the characteristics and the pathgenesis of lichen
striatus. Method : We clinically investigated 18
patients of lichen striatus that visited the department
of dematology at the Kyunghee medical center from
January 1995 to June 1998. Among them, 15 patients
had skin biopsies and were evaluated histopathologically
and immunohistochemically. Results : The results
were summarized as follows. 1. The male to female
ratio was 1:1.2, and average age was 13.4 years.
Interestingly three cases were adult onset lichen
striatus. The areas in which the eruptions developed
were (in descending order): upper extremity(61.1%),
lower extremity (22.2%), and trunk(16.7%). Among
them, two cases showed multiple skin lesions. 2.
Histopathologically, 9 cases showed superficial
perivascular dermatitis, 5 cases interface dermatitis,
1 case nodular dermatitis. Six cases showed inflammation
around hair follicle, 6 cases around eccrine sweat
gland. 3. Immunohistochemically, 11 cases showed
the predominance of CD8+ T cells beneath epidermis.
In the epidermis, the Langerhans cells increased
in 11 cases and the HLA-DR expression of keratinocytes
showed in all cases. Conclusion : In our study,
we were able to obtain the clinical and histopathological
features of lichen striatus which help to understand
the nature of lichen striatus. Immunohistochemical
findings suggest that cell mediated immune mechanism
is involved in pathogenesis of lichen striatus. |
