박정훈 ( Park Jeong Hun ) , 김낙인 ( Kim Nag In )
대한피부과학회 , 대한피부과학회지 | 42권 2호 138 ~ 144, 총 7 pages
Background: Psoriasis is a chronic skin disease characterized histologically by prominent keratinocyte hyperplasia and an early inflammatory cell infiltrate. However the pathogenesis is not fully understood yet. Recently, the evidence that T lymphocytes play a key tole in the pathogenesis of psoriasis is compelling. Objective: The purpose of this study is to cvaluate serum soluble E-selectin, MCP-1 and RANTES as severity indices of disease marker. In this study, we investigated a possible correlation between disease activity in psoriasis and serum soluble E-selectim, MCP-1 and RANTES, respectively. Methods: Fifteen patients with psoriasis and fifteen normal controls were included in this study. The patients were evaluated for the symptoms and signs accotding to PASI score. We measured soluble E-selectin, MCP-1 and RANTES levels with blood samples drawn from patients and normal controls. Results: １. Soluble E-selectin serum levels were significantly increased in psoriatic patients compared with normal controls (p＜0.05). Moreover, a significant correlation was demonstrated between serum soluble E-selectin values and PASI scores (r＝0.54, p＜0.05). ２. Serum MCP-1 levels were significantly increased in psoriatic patients compared with normal conrlos (p＜0.05). However, no significant correlation was observed between MCP-1 values and PASI scores (r＝0.12). ３. Serum RANTES levels were significantly increased in psoriatic patients compared with normal controls (p＜0.05). Moreover, a positive correlation was observed between serum RANTES levels and PASI scores (r＝0.63, p＜0.05). Conclusion: These results suggest that serum levels of soluble E-selectin and RANTES could be used as marker of the disease activity in psoriatic patients. (Korean J Dermatol 2004:42(2):138~144)
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