대피지
2002년 40권 5호 506 ~ 512
Background:
The pathogenesis of psoriasis remains uncertain. It is known that a variety of factors
take a role in its pathogenesis. One of them is the alteration of keratinocytes
differentiation. The terminal diffe rentiation of keratinocytes includes the process
of the synthesis of proteins such as involucrin, filaggrin, loricrin and cornifin,
and produce keratohyaline granules and a structure termed cornified cell envelope
finally. And the terminal differentiation of keratinocytes is known as a process
of apoptosis, programmed cell death.
Objective:
In this study, we tried to clarify the pathogenetic mechanisms of psoriasis by comparing
the expression patterns of several proteins(involucrin, loricrin, filaggrin) associated
with keratinocyte differentiation and of bcl-2 protein, known as inhibitor of apoptosis,
between lesional and non-lesional psoriatic skin.
Results:
The results wre summarized as follows, firstly early expression of involucrin in
lower epidermis, secondly no or reduced expression of filaggrin and loricrin in
upper epidermis and lastly no expression of bcl-2 in basal layer of psoriatic skin.
Conclusions:
This study clarified that the accelerated terminal differentiation, the shortening
of cell-cycle of keratinocytes, and the increased turnover of keratinocytes may
be involved in the pathogenetic role of psoriasis. |
