대피연지
1999;6;4 239-244
Lichen planus is a mucocutaneous disease of unknown etiology and pathogenesis. It
has been suggested that abnormal immune response is the basic underlying mechanism
in lichen planus. The aim of the present study was to verify the immunopathogenesis
of lichen planus by immunohistochemical study. In this study, 10 cases of lichen
planus were examined immunohistochemically with monoclonal antibodies against T
cell subsets(CD4, CD8), HLA-DR antigen and Langerhans cell. The results were as
follows: (1) Both subtypes of T lymphocytes were found in the dermis. Helper T cells
were predominate in seven cases but suppressor T cells were shown predominantly
in the other 3 cases. (2) The number of Langerhans cells in epidermis increased
in accordance with increased keratinocyte HLA-DR expression. In conclusion, these
findings support the hypothesis that lichen planus is a process mediated by immune
mechanism. |
