Annals of Dermatol 1999;11(4);292-296
Angiocentric
T-cell lymphomas have been described as a distinctive clinicopathologic entity in
the spectrum of peripheral T-cell lymphomas, with a prominent invasion of blood
vessels by lymphomatous cells. In these conditions, the presence of Epstein-Barr
virus (EBV) genomes has been demonstrated, suggesting that EBV might play a major
role in their cause. Herein, we report a case of cutaneous angiocentric T cell lymphoma
associated with the EBV. The patient was diagnosed with nasal angiocentric T cell
lymphoma 5 months ago, and treated with cyclophosphamide, doxorubicin, vincristine,
and prednisolone (CHOP) combination chemotherapy. After three cycles of CHOP, skin
lesions developed. A skin biopsy specimen showed an angiocentric and angioinvasive
infiltrate containing some atypical lymphocytes. EBV encoded RNA (EBER) was demonstrated
in lesional skin by in situ hybridization. (Ann Dermatol 11(4) 292~296,1999) |
