Annals of Dermatol 1998;10(3):179-184
Subcutaneous
panniculitic T-cell lymphoma(SPTCL) is a rare subtype of peripheral T-cell lymphoma
that clinically and histologically mimics benign panniculitis. SPTCL is characterized
by subcutaneous nodules on the extremities and trunk. It has a tendency to occur
mainly in female adults with eosinophilia, pruritus or hemophagocytic syndromes.
Histopathologically, typical lesions of SPTCL show moderate to dense lymphocytic
infiltrates in the subcutaneous fat, primarily involving the lobules. Early lesions
may show only focal lymphocytic atypia: later lesions display karyorrhexis, necrosis
and cytophagia. A 34-year-old woman presented with multiple, recurrent, tender subcutaneous
nodules on the abdomen and extremities which she had had for 13 years. There was
no hepatosplenomegaly or lymphadenopathy. Skin biopsy specimens revealed atypical
small and large lymphocytic infiltrations in the subcutaneous tissue. Occasionally,
histiocytes contained erythrocytes and lymphocytes in their cytoplasm. Immunohistochemical
staining showed positive reactions to CD45RO and CD43. Negative reactions were seen
to CD20, Leu-7 and lysoryme antigen. On the basis of the clinical & histological
findings, we established the diagnosis of SPTCL. (Ann Dermatol 10:(3) 179~184, 1998). |
